许利耕 副教授

发布时间:2016-12-09访问量:907设置

学习与工作经历

2017.07-至今苏州大学,功能纳米与软物质研究院,副教授

2017.07-2018.07   美国北卡罗来纳大学教堂山分校(UNC Chapel Hill),药学院,访问学者

2012.08-2017.06   苏州大学,功能纳米与软物质研究院,讲师

2008.09-2012.07   国家纳米科学中心,物理化学,理学博士

2005.09-2008.07   西北农林科技大学,细胞生物学,理学硕士

2001.09-2005.07   西北农林科技大学,动物医学,农学学士

  

研究方向

(1) 纳米材料的免疫学效应研究;

(2) 纳米材料潜在疫苗佐剂活性研究;

(3) 基于纳米材料的肿瘤免疫治疗新策略。

  

学术成果

近年来主要从事纳米材料的免疫学效应及其在肿瘤免疫治疗中的潜在应用研究,发展了一系列具有疫苗佐剂功能的新型纳米材料(例如金纳米棒、富勒烯衍生物、氧化石墨烯、上转换纳米颗粒和共轭高分子聚合物)和基于纳米材料的新型肿瘤免疫联合治疗新策略,已在国际学术期刊上发表SCI论文30余篇。其中,以第一作者和通讯作者身份发表SCI论文18篇,累计影响因子大于150,部分研究成果发表于Nat. Commun.(2), Adv. Mater.(1), Nano Lett.(1), ACS Nano(3), Adv. Funct. Mater.(1), Nanoscale(2)等国际权威期刊,影响因子大于108篇,文章他引次数 >1500H-index19。参编中文学术专著 (科学出版社)1部,英文学术专著 (Wiley出版社)2部,主编出版国内第一本纳米生物学本科实验教材(科学出版社十三五规划教材),授权国家发明专利4项。主持NSFC青年科学基金、中国博士后科学基金面上基金(一等资助)和中科院纳米生物效应与安全性重点实验室开放课题各1项。应邀担任多个国际著名期刊包括Advanced Materials, ACS Nano, Advanced Functional Materials, Chemistry of Materials, Biomaterials, Theranostics, NanoscaleACS Applied Materials& Interfaces等审稿人。

  

获得荣誉

1. ACS Nano Young Scientist Award (International Conference of ChinaNanomedicine 2016, 武汉)

2. Award of Teaching Excellencein 2015 (纳米科学技术学院, 苏州大学)

  

代表性论文 (#共同第一作者,*通讯作者)

https://scholar.google.com/citations?user=g-VNF7wAAAAJ&hl=en


[1] Rong Yang, Jun Xu, Ligeng Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng*, Zhuang Liu*. Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination. ACS Nano, 2018, DOI: 10.1021/acsnano.7b09041 (IF=13.334).

[2] Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li*, Rui Peng, Zhuang Liu*. Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer. Nano Letters, 2018, 18, 2475-2484 (IF=13.779).

[3] Qian Chen, Ligeng Xu, Jiawen Chen, Zhijuan Yang, Chao Liang, Yu Yang, Zhuang Liu*.Tumor vasculature normalization by orally federlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy. Biomaterials, 2017, 148, 69-80 (IF=8.4).

[4] Guangbao Yang#, Ligeng Xu#, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu*. Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nature Communications, 2017, 8, DOI: 10.1038/s41467-017-01050-0. (IF=11.329)

[5] Jun Xu, Ligeng Xu*, Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu, Rui Peng*, Zhuang Liu*. Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer. ACS Nano, 2017, 11, 4463-4474 (IF=13.334, Web of Science 高被引论文).

[6] Jingjing Liu, Kai Liu, Liangzhu Feng, Zhuang Liu, Ligeng Xu*. Comparison of nanomedicine-based chemotherapy, photodynamic therapy and photothermal therapy using reduced graphene oxide for the model system. Biomaterials Science, 2017, 5, 331-340. (IF=3.614)

[7] Qian Chen#, Ligeng Xu#, Chao Liang, Chao Wang, Rui Peng, Zhuang Liu*. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nature Communications, 2016, 7, DOI:10.1038/ncomms13193. (IF=11.329)

[8] Wenwen Zhu, Ziliang Dong, Tingting Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, Zhuang Liu*. Modulation of hypoxia in solid tumor microenvironment with MnO2 nanoparticles to enhance photodynamic therapy. Advanced Functional Materials, 2016, 26, 5490-5498 (IF= 11.382, Web of Science 高被引论文, 热点论文)

[9] Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu*, Rui Peng*. Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity. Nanoscale, 2016, 8, 3785-3795. (IF= 7.76, 2016 Hot Articles in Nanoscale)

[10] Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao, Rui Peng*. Functionalized graphene oxide in microbial engineering: an effective stimulator for bacterial growth. Carbon, 2016, 103, 172-180. (IF=6.198)

[11] Ligeng Xu, Jian Xiang, Rui Peng*, Zhuang Liu*. Recent advances in the development of nanomaterials for DC-based immunotherapy. Science Bulletin, 2016, 61, 514-523. (Invited review, IF=1.789)

[12] Chao Liang, Ligeng Xu, Guosheng Song, Zhuang Liu*. Emerging nanomedicine approaches for tumor metastasis treatment. Chemical Society Reviews, 2016, 45, 6250-6269. (Invited review, IF=34.09)

[13] Hua Gong, Jian Xiang,Ligeng Xu*, Xuejiao Song, Ziliang Dong, Rui Peng*, Zhuang Liu*. Stimulation of immune systems by conjugated polymers and their potential as an alternative vaccine adjuvant. Nanoscale, 2015, 7, 19282-19292. (IF= 7.76)

[14] Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*, Zhuang Liu*. Antigen-loaded upconversion nanoparticles for dendritic cell stimulation, tracking, and vaccination in dendritic cell-based immunotherapy. ACS Nano, 2015, 9, 6401-6411. (IF= 13.334)

[15] Liming Qu, Jinhai Xu, Xiaofang Tan, Zhuang Liu, Ligeng Xu*, Rui Peng*. Dual-aptamer modification generates a unique interface for highly sensitive and specific electrochemical detection of tumor cells. ACS Applied Materials & Interfaces, 2014, 6, 7309-7315. (IF=7.145)

[16] Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, Zhuang Liu*. Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis. Advanced Materials, 2014, 26, 8154-8162 (IF=18.96)

[17] Ligeng Xu, Liang Cheng, Chao Wang, Rui Peng*, Zhuang Liu*. Conjugated polymers for photothermal therapy of cancer. Polymer Chemistry, 2014, 5, 1573-1580. (Invited review, IF=5.520, 2014’smost accessed Polymer Chemistry Top10 articles)

[18] Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Liying Ma, Yiming Shao*, Yuliang Zhao*, Chunying Chen*. Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine. Advanced Materials, 2013, 25, 5928-5936.  (IF=18.96, Highlighted by MaterialsViews China)

[19]Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Yong Liu, Xiaochun Wu*, Yinglu Ji, Yuliang Zhao, Liying Ma, Yiming Shao, Chunying Chen*. Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment. Nano Letters, 2012, 12, 2003-2012. (IF=13.779, Web of Science高被引论文)

[20] Ligeng Xu, Chunying Chen*. Physiological behavior of quantum dots. WIRES Nanomedicine Nanobiotechnology, 2012, 4, 620-637. (Invited review, IF=4.095)

[21] 许利耕, 陈春英*. 纳米材料作为重大疾病疫苗载体或佐剂的研究进展. 科学通报, 2012, 57, 2341-2353 (封面文章).

[22] Ligeng Xu, Ying Liu, Ru Bai, Chunying Chen*. Applications and toxicological issues surrounding nanotechnology in the food industry. Pure and Applied Chemistry, 2010, 82, 349-372 (Invited review, IF=2.615).


参编专著:

[1] Ligeng Xu, Xuejiao Song, Zhuang Liu*. Conjugated polymers for biological and biomedical applications (Chapter 11: Near-Infrared Conjugated Polymers for Photothermal Therapy.) Wiley-VCH Verlag GmbH & Co. KGaA, 2018, ISBN: 978-3-527-34273-0.

[2] Ligeng Xu, Chunying Chen*. Chapter 8: Modulation of the immune system by fullerene and graphene derivatives. In: Biomedical applications and toxicology of carbon nanomaterials. Wiley-VCH Verlag GmbH & Co. KGaA, 2016, 213-238, ISBN: 9783527338719.

[3] 许利耕, 陈春英*.《二氧化钛纳米材料的制备、表征及安全应用》(第六章: 二氧化钛纳米材料与生物体的相互作用及其与纳米特性的相关性), 科学出版社, 2014, ISBN: 9787030400710.

  

主编教材

刘庄, 许利耕, 主编。《纳米生物学交叉实验教程》, 科学出版社(普通高等教育 “十三五规划教材), 2017, ISBN: 978-7-03-055171-9.

  

申请与授权专利 (本人均为实际完成人)

[1] 刘庄,许利耕,陈倩. 一种二氧化锰纳米佐剂及其制备方法、应用. 专利申请号:201710795715.4.

[2] 陈春英, 许利耕, 吴晓春. 金纳米棒的修饰方法及金纳米棒-功能分子复合体. 专利授权号:ZL201010274005.

[3] 陈春英, 许利耕. 纳米颗粒的制备方法及用该方法制备的纳米颗粒. 专利授权号:ZL201010274003.

[4] 陈春英, 邵一鸣, 许利耕, 郝彦玲, 刘颖, 刘野. 富勒烯衍生物在制备用于基因传递的载体中的应用. 专利授权号: ZL201010621120.5.

[5] 陈春英,邵一鸣,许利耕,郝彦玲,刘颖,刘野. 富勒烯衍生物及其疫苗佐剂和疫苗制剂.专利授权号: ZL201310357325.

  

Tel: 0512-65880927

E-mail: lgxu@suda.edu.cn


责任编辑:钟帅


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