刘庄教授课题组同威斯康辛大学Weibo Cai教授课题组合作在ACS Nano上发表论文

题目：

Iron Oxide Decorated MoS₂ Nanosheets with Double PEGylation for Chelator-Free Radiolabeling and Multimodal Imaging Guided Photothermal Therapy

作者：

Teng Liu ^†, Sixiang Shi ‡, Chao Liang ^†, Sida Shen ^†, Liang Cheng ^†, Chao Wang^†, Xuejiao Song ^†, Shreya Goel^‡, Todd E. Barnhart ^§, Weibo Cai ^*‡§∥⊥, and Zhuang Liu ^*†

单位：

^†Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123,China

^‡Materials Science Program, ^§Department of Medical Physics, and ^∥Department of Radiology, University of Wisconsin−Madison, Madison, Wisconsin, United States

^⊥University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States

摘要：

MoS₂-IO nanocomposites, which are then modified with two types of polyethylene glycol (PEG) to acquire enhanced stability in physiological environments. Interestingly, ⁶⁴Cu, a commonly used positron-emitting radioisotope, could be firmly adsorbed on the surface of MoS₂ without the need of chelating molecules, to enable in vivo positron emission tomography (PET) imaging. On the other hand, the strong near-infrared (NIR) and superparamagnetism of MoS₂-IO-PEG could also be utilized for photoacoustic tomography (PAT) and magnetic resonance (MR) imaging, respectively. in vivo photothermal therapy is finally conducted, achieving effective tumor ablation in an animal tumor model.

影响因子：

12.033

分区情况：

1区

链接：

http://pubs.acs.org/doi/abs/10.1021/nn506757x

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