执行院长 刘庄教授

发布时间:2016-12-16访问量:130设置



学术经历:

        2004年北京大学化学与分子工程学院获理学学士学位;2008年美国斯坦福大学(Stanford University)获得化学博士学位;2008年至2009年在斯坦福大学化学系以及医学院从事博士后研究。20096月加入苏州大学功能纳米与软物质研究院,被聘为教授、博士生导师。


主要成果和贡献:

近年来一直在纳米医学与肿瘤纳米技术领域从事研究。2005年以来发表学术论文190余篇,相当一部分成果发表于Chem. Rev., Chem. Soc. Rev., Angew.  Chem. Int. Ed., JACS, Adv. Mater., Ad. Funct. Mater. Nano Lett., ACS Nano,  Nature Protocols等国际权威刊物上。论文总引用超过22,000次,SCI H-index7020142015年连续入围Elsevier出版社发布的“中国高被引用学者榜单”(材料科学类);2015年入选美国汤森路透集团(Thomson Reuters)公布的全球高被引科学家名单Highly Cited Researchers  2015(化学、材料)。获国家杰出青年基金、基金委优秀青年基金、江苏省杰出青年基金的资助。

本课题组的研究领域是纳米生物材料与纳米医学,这是一门跨越材料、化学、生物医学的新兴交叉学科。我们的目标是开发新型功能纳米材料,通过结构设计、可控合成、和合理的表面修饰得到功能丰富的且生物相容性良好纳米材料,研究其在生命体系中的行为,并利用纳米材料独特的物理与化学性质以发展新型多模态生物影像技术、靶向药物输送技术、以及肿瘤物理治疗技术,从而探索癌症的诊断与治疗的新思路与新方法。主要研究方向如下:

- 新型无机功能纳米材料在多模态生物成像与肿瘤联合治疗中的应用

- 高分子纳米药物载体与肿瘤联合治疗

- 基于生物材料(细胞载体、蛋白载体等)的肿瘤光学治疗与联合治疗研究

- 基于功能纳米材料的肿瘤放射治疗

- 纳米技术与肿瘤免疫治疗

- 纳米材料的生物学效应与生物安全性研究


获得奖励:

2016年入选科技部中青年科技创新领军人才

2015年获国家杰出青年基金资助

2015年入选中组部万人计划青年拔尖人才

2015年受邀成为英国皇家化学会会士

2014年获教育部自然科学二等奖(第一完成人)

2014年获中国化学会青年化学奖

2014年获霍英东基金委青年教师奖

2013年入选百千万人才工程国家级人选

2013年获江苏省杰出青年基金资助

2013年获Asian Rising Stars15th Asian Chemistry Congress,  Singapore

2012年获国家自然科学基金委优秀青年基金资助

2012年获苏州大学周氏教育科研奖科研类优异奖

2012年获SCOPUS“寻找青年科学之星银奖(材料类)

2011年获国家人力资源和社会保障部高层次留学人才回国资助

2011年入选江苏省“333高层次人才培养计划第二层次

2008年获MRS Silver AwardMaterials Research Society,  USA


期刊编委:

Associate Editor, Biomaterials  (2014-)

Editorial Board Member, Nano  Research (2014-)

Editorial Board Member, Scientific  Reports (NPG, 2013- )

Editorial Board Member, American  Journal of Nuclear Medicine and Molecular Imaging (2012- )

Guest Editor, Nanoscale  (2015)

Guest Editor, Carbon (2015)

Guest Editor, Advanced Healthcare  Materials (2014)

Guest Editor, Theranostics  (2012)


招生方向:本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生和博士研究生到课题组学习工作。招生方向包括无机化学04方向),材料学03方向),以及生物化学与分子生物学01-03方向)。欢迎具有化学、材料、或生物医学背景的同学报考。有疑问请随时邮件联系zliu@suda.edu.cn


招聘信息:根据课题组发展需要,现拟招收1-2名从事纳米医学研究领域的博士后研究人员,纳米毒理学、医学免疫学、高分子药物载体相关研究方向的申请者优先考虑。有意者请发送简历至zliu@suda.edu.cn


发表论文:

http://www.researcherid.com/rid/H-4352-2011

http://scholar.google.com/citations?hl=en&user=AIJbgl0AAAAJ


近期代表性论文:

[52] Chao Liang, Ligeng Xu, Guosheng  Song, Zhuang Liu*. “Emerging nanomedicine approaches fighting tumor metastasis:  animal models, metastasis-targeted drug delivery, phototherapy, and  immunotherapy” Chem. Soc. Rev. DOI:  10.1039/C6CS00458J

[51] Qian Chen, Liangzhu Feng,  Jingjing Liu, Wenwen Zhu, Ziliang Dong, Yifan Wu, Zhuang Liu*. “Intelligent  Albumin–MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to  Modulate Tumor Hypoxia for Effective Combination Therapy” Adv. Mater. DOI:  10.1002/adma.201601902

[50] Kai Yang*, Liangzhu Feng,  Zhuang Liu*. “Stimuli responsive drug delivery systems based on nano-graphene  for cancer therapy” Adv. Drug Deliv.  Rev. DOI:  org/10.1016/j.addr.2016.05.015

[49] Qian Chen, Zhuang Liu*.  “Albumin carriers for cancer theranostics: a conventional platform with new  promises” Adv.  Mater.  DOI:10.7150/thno.14431

[48]Song Guosheng, Chen Yuyan, Liang  Chao, Yi Xuan, Liu Jingjing, Sun Xiaoqi, Shen Sida, Yang Kai, Zhuang Liu*.  “Catalase-loaded TaOx Nanoshells as Bio-nanoreactors Combining High-Z Element  and Enzyme Delivery for Enhancing Radiotherapy” Adv. Mater. DOI:  10.1002/adma.201602111

[47]Guosheng Song, Chao Liang, Xuan Yi,  Qi Zhao, Liang Cheng, Kai Yang, Zhuang Liu*., Perfluorocarbon Loaded Hollow  Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to  Enhance Radiotherapy of Cancer Adv. Mater. 28, 2716–2723 (2016)

[46]Wenwen Zhu, Ziliang Dong, Tingting  Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, Zhuang Liu*.  “Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles  to Enhance Photodynamic Therapy” Adv. Funct.  Mater. 26,  5490–5498 (2016)

[45] Liang Cheng*, Sida Shen,  Sixiang Shi, Yuan Yi, Xiaoyong Wang, Guosheng Song, Kai Yang, Gang Liu, Todd E.  Barnhart, Weibo Cai*, Zhuang Liu*. “FeSe2-Decorated Bi2Se3 Nanosheets Fabricated  via Cation Exchange for Chelator-Free 64Cu-labeling and Multimodal Image-Guided  Photothermal-Radiation Therapy” Adv. Funct.  Mater. 26,  2185–2197 (2016)

[44] Guangbao Yang, Xiaoqi Sun,  Jingjing Liu, Liangzhu Feng, Zhuang Liu*. “Light-responsive, Singlet  Oxygen–triggered On-demand Drug Release from Photosensitizer-doped Mesoporous  Silica Nanorods for Cancer Combination Therapy” Adv. Funct.  Mater. 26,  4722–4732 (2016)

[43] Hua Gong, Yu Chao, Jian Xiang,  Xiao Han, Guosheng Song, Liangzhu Feng, Jingjing Liu, Guangbao Yang, Qian Chen,  Zhuang Liu*. “Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor  Therapy” Nano  Lett. 16 ,  2512–2521 (2016)

[42] Guangbao Yang, Jingjing Liu,  Yifan Wu, Liangzhu Feng*,Zhuang Liu*. “Near-Infrared-light responsive nanoscale  drug delivery systems for cancer treatment” Coordin. Chem.  Rev.  320-321,100-117 (2016)

[41] Liangzhu Feng, Min Gao, Danlei  Tao, Qian Chen, Hairong Wang, Ziliang Dong, Meiwan Chen*, Zhuang Liu*.  “Cisplatin-prodrug-constructed liposomes as a versatile theranostic  nano-platform for bimodal imaging guided combination cancer therapy”  Adv. Funct.  Mater. 26(13):  2207-2217 (2016)

[40] Yu Yang, Jingjing Liu, Chao  Liang, Liangzhu Feng, Tingting Fu, Ziliang Dong, Yu Chao, Yonggang Li, Guang  Lu*, Meiwan Chen*, Zhuang Liu*. “Nanoscale Metal-Organic Particles with Rapid  Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy”  ACS Nano,  10(2):  2774-2781 (2016)

[39] Guosheng Song, Jiali Hao, Chao  Liang, Teng Liu, Min Gao, Liang Cheng, Junqing Hu*, Zhuang Liu*. “Degradable  Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing  Capabilities as a Novel Therapeutic Nano-platform” Angew. Chem. Int. Ed.  55, 2122–2126  (2016)

[38] Liang Cheng*, Chao Yuan, Sida  Shen, Xuan Yi, Hua Gong, Kai Yang, Zhuang Liu*, “Bottom-Up Synthesis of  Metal-Ion-Doped WS2 Nanoflakes for Cancer Theranostics”  ACS  Nano, 9,  11090-11101 (2015).

[37] Xiaoyan Zhong, Kai Yang*,  Zhiliang Dong, Xuan Yi, Yong Wang, Cuicui Ge, Yuliang Zhao, Zhuang Liu*,  Polydopamine as a biocompatible multifunctional nano-carrier for combined  radioisotope therapy & chemotherapy of cancer Adv. Funct.  Mater. 25,  7327–7336 (2015)

[36] Qian Chen, Xiaodong Liu, Jiawen  Chen, Jianfeng Zeng*, Zhenping Cheng, Zhuang Liu* “A Self-assembled  Albumin-based Nanoprobe for in vivo Ratiometric Photoacoustic pH Imaging”  Adv.  Mater. 27,  6820–6827 (2015)

[35] Guosheng Song, Chao Liang, Hua  Gong, Meifang Li, Xianchuang Zheng, Liang Cheng, Kai Yang*, Xiqun Jiang, Zhuang  Liu*, “Core-Shell MnSe@Bi2Se3 Fabricated via a Cation Exchange Method as Novel  Nanotheranostics for Multimodal Imaging and Synergistic Thermo-radiotherapy”  Adv.  Mater. 27,  6110–6117(2015)

[34] Xuan Yi, Kai Yang*, Chao Liang,  Xiaoyan Zhong, Ping Ning, Guosheng Song, Dongliang Wang, Cuicui Ge, Chunying  Chen, Zhifang Chai and Zhuang Liu*, “Imaging-Guided Combined Photothermal and  Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped  Copper Sulfide Nanoparticles” Adv. Funct. Mater.  25(29),  4689-4699(2015)

[33] Jian Xiang, Ligeng Xu*, Hua  Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*,  Zhuang Liu*,Antigen-Loaded Upconversion  Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in  Dendritic Cell-Based Immunotherapy” ACS Nano,  9,  6401-6411 (2015)

[32] Qian Chen, Xin Wang, Chao Wang,  Liangzhu Feng, Yonggang Li, Zhuang Liu* “Drug-Induced Self-Assembly of Modified  Albumins as Nano-theranostics for Tumor-Targeted

Combination  Therapy” ACS  Nano, 9,  5223-5233 (2015)

[31] Xiaoqi Sun, Chao Wang, Min Gao,  Aiyan Hu, Zhuang Liu* “Remotely controlled red blood cell carriers for cancer  targeting and near-infrared light-triggered drug release in combined  photothermal-chemotherapy”Adv. Funct. Mater.  25, 2386–2394  (2015)

[30] Teng Liu, Sixiang Shi, Chao Liang,  Sida Shen, Liang Cheng, Chao Wang, Xuejiao Song, Shreya Goel, Todd E. Barnhart,  Weibo Cai*, Zhuang Liu* “Iron Oxide Decorated MoS2 Nanosheets with Double  PEGylation for Chelator-Free Radiolabeling and Multimodal Imaging Guided  Photothermal Therapy” ACS Nano, 9, 950-960 (2015)

[29] Qian Chen, Chao Liang, Chao Wang, Zhuang  Liu*, “An Imagable and Photothermal “Abraxane-Like” Nanodrug for Combination  Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors”  Adv. Mater.  27, 903-910,  (2015)

[28]Jingjing Liu,  Chao Wang, Xiaojing Wang, Xin Wang, Liang Cheng, Yonggang Li, Zhuang Liu*  “Mesoporous Silica Coated Single-Walled Carbon Nanotubes as a Multifunctional  Light-Responsive Platform for Cancer Combination Therapy” Adv. Funct. Mater.  25, 384–392  (2015)

[27] Chao Wang, Ligeng Xu, Chao Liang,  Jian Xiang, Rui Peng, Zhuang Liu* “Immunological responses triggered by  photothermal therapy with carbon nanotubes in combination with anti-CTLA-4  therapy to inhibit cancer metastasis” Adv. Mater.26, 8154-8162  (2014)

[26] Liang Cheng, Chao Wang, Liangzhu  Feng, Kai Yang, Zhuang Liu* “Functional Nanomaterials for Phototherapies of  Cancer” Chem.  Rev. 114(21), 10869-10939  (2014)

[25]Hua Gong, Ziliang Dong, Yumeng Liu,  Shengnan Yin, Liang Cheng, Wenyao Xi, Jian Xiang, Kai Liu, Yonggang Li, Zhuang  Liu* “Engineering of multifunctional nano-micelles for combined photothermal  & photodynamic therapy under the guidance of multimodal imaging”  Adv. Funct.  Mater.24, 6492-6502 (2014)

[24]Chao Liang, Shuo Diao, Chao Wang,  Hua Gong, Teng Liu, Guosong Hong, Xiaoze Shi, Hongjie Dai*, Zhuang Liu* “Tumor  Metastasis Inhibition by Imaging-guided Photothermal Therapy with Single-walled  Carbon Nanotubes”  Adv. Mater. 26,  5646-5652 (2014)

[23] Chao Wang, Xiaoqi Sun, Liang  Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*, “Multifunctional  theranostic red blood cells for magnetic field enhanced in vivo combination  therapy of cancer” Adv. Mater. 26, 4794-4802 (2014)

[22] Liang Cheng, Wenjing Huang,  Qiufang Gong, Changhai Liu, Zhuang Liu*, Yanguang Li* and Hongjie Dai  “Ultra-Thin WS2 Nanoflakes as a Highly Efficient Electrocatalyst for Hydrogen  Evolution Reaction” Angew. Chem. Int.  Ed. 53, 7860-7863  (2014)

[21] Teng Liu, Chao Wang, Xing Gu,  Hua Gong, Liang Cheng, Xiaoze Shi, Liangzhu Feng, Baoquan Sun, Zhuang Liu*  PEGylated MoS2 nano-sheets as a highly efficient versatile drug loading  platform for combined chemo-&photothermal therapy of cancer Adv. Mater. 26, 3433–3440 (2014)

[20]Liang Cheng, Jingjing Liu, Xing Gu,  Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong  Xing, Wenbo Bu, Baoquan Sun, Zhuang Liu* “PEGylated WS2 nanosheets as a multifunctional  theranostic agent for in vivo dual-modal CT / photoacoustic imaging guided  photothermal therapy” Adv. Mater.26, 1886–1893, (2014)

[19] Zhiwei Li, Shengnan Yin, Liang  Cheng, Kai Yang, Yonggang Li, Zhuang Liu* “Magnetic Targeting Enhanced  Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of  Cancer” Adv.  Funct. Mater.  24, 2312-2321 (2014)

[18] Xuejiao Song, Hua Gong,  Shengnan Yin, Liang Cheng, Chao Wang, Zhiwei Li, Yonggang Li, Xiaoyong Wang,  Gang Liu, Zhuang Liu* Ultra-small Iron Oxide Doped Polypyrrole Nanoparticles  for in vivo Multimodal Imaging Guided Photothermal Therapy Adv. Funct. Mater.  24, 1194–1201  (2014)

[17] Hua Gong, Rui Peng*, Zhuang  Liu* “Carbon nanotubes for biomedical imaging: The recent advances”  Adv. Drug  Delivery Rev.65, 1951–1963 (2013)  

[16] Kai Yang, Liangzhu Feng, Hao  Hong, Weibo Cai, Zhuang Liu*. “Preparation and functionalization of graphene  nanocomposites for biomedical applications” Nature  Protocols,  8, 2392-2403 (2013)  

[15] Chao Wang, Huan Xu, Chao Liang,  Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li, Zhuang Liu*  “Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for  Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect”ACS  Nano, 7,  6782–6795 (2013)

[14] Chao Wang, Liang Cheng, Xinxing  Ma, Xiaojing Wang, Yumeng Liu, Zhaoyi Deng, Yonggang Li, Zhuang Liu*  “Imaging-guided pH Sensitive Photodynamic Therapy using Charge Reversible  Upconversion Nanoparticles under Near-Infrared Light” Adv. Funct. Mater.  23, 3077-3086  (2013)

[13] Liang Cheng, Chao Wang, Xinxing  Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu*  “Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem  Cell Therapy under Remote Magnetic Control” Adv. Funct. Mater.  23, 272-280  (2013)

[12] Kai Yang, Liangzhu Feng, Xiaoze  Shi, Zhuang Liu* “Nano-graphene in biomedicine: theranostic applications”  Chem. Soc. Rev.  42, 530-547  (2013) (2013年中国百篇最具影响国际学术论文)

[11] Liang Cheng, Chao Wang, Xinxing  Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu*  “Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem  Cell Therapy under Remote Magnetic Control” Adv. Funct.  Mater. 23, 272-280 (2013)

[10] Kai Yang, Huan Xu, Liang Cheng,  Chunyang Sun, Jun Wang, Zhuang Liu* “In vitro and in vivo near-infrared  photothermal therapy of cancer using polypyrrole organic  nanoparticles”Adv. Mater.24, 5586-5592  (2012)

[9] Liang Cheng, Kai Yang, Qian  Chen, Zhuang Liu*, “Organic Stealth Nanoparticles for Highly Effective in Vivo  Near-Infrared Photothermal Therapy of Cancer” ACS Nano,6, 5605–5613 (2012)  (Reported by C&E News)

[8] Xiaojing Wang, Chao Wang, Liang  Cheng, Shuit-Tong Lee, Zhuang Liu* “Noble Metal Coated Single-walled Carbon  Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and  Photothermal Therapy” J. Am. Chem. Soc.  134, 7414–7422  (2012)

[7] Kai Yang, Lilei Hu, Xingxing Ma,  Shuoqi Ye, Liang Cheng, Xiaoze Shi, Changhui Li, Yonggang Li, Zhuang Liu*  “Multimodal imaging guided photothermal therapy using functionalized graphene  nano-sheets anchored with magnetic nanoparticles” Adv. Mater. 24, 1868-1872 (2012) (Frontispieces  Feature)

[6] Chao Wang, Xinxing Ma, Shouqi  Ye, Liang Guo, Changhui Li, Yonggang Li*, Zhuang Liu* “Protamine functionalized  single-walled carbon nanotubes for stem cell labeling and in vivo Raman /  magnetic resonance / photoacoustic triple-modal imaging” Adv. Funct. Mater.  22, 2363–2375  (2012)

[5] Bo Tian, Chao Wang, Shuai Zhang,  Liangzhu Feng, Zhuang Liu* “Photothermally Enhanced Photodynamic Therapy  Delivered by Nano-Graphene Oxide” ACS Nano, 5, 7000-7009 (2011)

[4] Liang Cheng, Kai Yang, Yonggang  Li, Jianhua Chen, Chao Wang, Mingwang Shao*, Shuit-Tong Lee, Zhuang Liu* “Facile  preparation of multifunctional upconversion nanoprobes for multi-modal imaging  and dual-targeted photothermal therapy” Angew. Chem. Int.  Ed.  50, 7385-7390  (2011)

[3] Kai Yang, Jianmei Wan, Shuai  Zhang, Youjiu Zhang, Shuit-Tong Lee, Zhuang Liu* “In vivo Pharmacokinetics,  Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice”  ACS  Nano, 5,  516-522 (2011)

[2] Chao Wang, Liang Cheng, Zhuang  Liu,* “Drug Delivery with Upconversion Nanoparticles for Multi-Functional  Targeted Cancer Cell Imaging and Therapy” Biomaterials,32, 1110-1120 (2011)  (2011年中国百篇最具影响国际学术论文)

[1] Kai Yang, Shuai Zhang, Guoxin  Zhang, Xiaoming Sun, Shuit-Tong Lee and Zhuang Liu,* “Graphene in Mice –  Ultra-high in vivo Tumor Uptake and Highly Efficient Photothermal Therapy”  Nano Lett.  10, 3318–3323  (2010)(Highlighted by Nature)


联系电话:0512-65882036

E-mail: zliu@suda.edu.cn

课题组网页:http://nano.suda.edu.cn/lz


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