刘庄教授课题组与程亮教授课题组合作在ACS Nano上发表论文

题目：

Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy

作者：

Shang Bai, Nailin Yang, Xianwen Wang, Fei Gong, Ziliang Dong, Yuehan Gong, Zhuang Liu*, and Liang Cheng*

单位：

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional 

Materials and Devices, Soochow University, Suzhou 215123, People’s Republic of China

摘要：

Sonodynamic therapy (SDT), which can generate reactive oxygen species (ROS) based on sonosensitizers under ultrasound (US) to kill tumor cells, has emerged as a noninvasive therapeutic modality with high tissue-penetration depth. Herein, ultrasmall iron-doped titanium oxide nanodots(Fe-TiO₂ NDs) are synthesized via a thermal decomposition strategy as a type of sonosensitizers to enhance SDT. Interestingly, the Fe doping in this system appears to be crucial in not only enhancing the US-triggered ROS generation of those NDs but also offering NDs the Fenton-catalytic function to generate ROS from tumor endogenous H₂O₂ for chemodynamic therapy (CDT). After polyethylene glycol (PEG) modification, Fe-TiO₂-PEG NDs demonstrate good physiological stability and biocompatibility. With efficient tumor retention after intravenous injection as revealed by in vivo magnetic resonance (MR) and fluorescent imaging, our Fe-TiO₂ NDs demonstrate much better in vivo therapeutic performance than commercial TiO₂ nanoparticles owing to the combination of CDT and SDT. Moreover, most of those ultrasmall Fe-TiO₂ NDs can be effectively excreted within one month, rendering no obvious long-term toxicity to the treated mice. Our work thus presents a type of multifunctional sonosensitizer for highly efficient cancer treatment via simply doping TiO₂ nanostructures with metal ions.

影响因子：

14.588

分区情况：

一区

链接：

 https://dx.doi.org/10.1021/acsnano.0c05235