刘庄教授课题组与浙江大学李翔副教授合作在Advanced Materials发表论文

发布时间:2019-03-07访问量:10设置

题目:

Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment

作者:

Tongxu Gu1, Yao Wang1, Yunhao Lu1, Liang Cheng2, Liangzhu Feng2, Hui Zhang1, Xiang Li1*, Gaorong Han1*, and Zhuang Liu2*

单位:

1State Key Laboratory of Silicon Materials School of Materials Science and Engineering, Zhejiang University Hangzhou, Zhejiang 310027, P. R. China

2Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, P. R. China

摘要:

Electrochemical therapy (EChT), by inserting electrodes directly into tumors to kill cancer cells under direct current (DC), is clinically used in several countries. In EChT, the drastic pH variation nearby the inserted electrodes is the main cause of tumor damage. However, its limited effective area and complex electrode configuration have hindered the clinical application of EChT in treating diverse tumor types. Herein, a conceptually new electric cancer treatment approach is presented through an electro-driven catalytic reaction with platinum nanoparticles (PtNPs) under a square-wave alternating current (AC). The electric current triggers a reaction between water molecules and chloride ions on the surface of the PtNPs, generating cytotoxic hydroxyl radicals. Such a mechanism, called electrodynamic therapy (EDT), enables effective killing of cancer cells within the whole electric field, in contrast to EChT, which is limited to areas nearby electrodes. Remarkable tumor destruction efficacy is further demonstrated in this in vivo EDT treatment with PtNPs. Therefore, this study presents a new type of cancer therapy strategy with a tumor-killing mechanism different from existing methods, using nanoparticles with electrocatalytic functions. This EDT method appears to be minimally invasive, and is able to offer homogeneous killing effects to the entire tumor with a relatively large size.

影响因子:

21.95

分区情况:

一区

链接:

https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201806803


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