刘庄教授课题组在Advanced Materials上发表论文

发布时间:2019-03-07访问量:10设置

题目:

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

作者:

Qian Chen, Jiawen Chen, Zhijuan Yang, Jun Xu, Ligeng Xu, Chao Liang, Xiao Han, and Zhuang Liu*

单位:

Institute of Functional  Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University Suzhou, Jiangsu 215123, China

摘要:

External radiotherapy is extensively used in clinic to destruct tumors by locally applied ionizing-radiation beams. However, the efficacy of   radiotherapy is usually limited by tumor hypoxia-associated radiation   resistance. Moreover, as a local treatment technique, radiotherapy can hardly control tumor metastases, the major cause of cancer death. Herein, core–shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H2O2 to generate O2, inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like-receptor-7 agonist, within the PLGA shell. The formed PLGA-R837@Cat nanoparticles can greatly enhance radiotherapy efficacy by relieving the tumor hypoxia and modulating the immune-suppressive tumor microenvironment. The tumor-associated antigens generated  postradiotherapy-induced immunogenic cell death in the presence of such R837-loaded adjuvant nanoparticles will induce strong antitumor immune responses, which together with cytotoxic T-lymphocyte associated protein 4 (CTLA-4) checkpoint blockade will be able to effectively inhibit tumor metastases by a strong abscopal effect. Moreover, a long term immunological memory effect to protect mice from tumor rechallenging is observed post such treatment. This work thus presents a unique nanomedicine approach as a next-generation radiotherapy strategy to enable synergistic whole-body therapeutic responses after local treatment, greatly promising for clinical translation.

影响因子:

21.95

分区情况:

一区

链接:

https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201802228


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