程亮副教授与威斯康辛大学Weibo Cai教授课题组合作在ACS Nano上发表论文

发布时间:2016-10-26访问量:1065设置

题目:

Dual-Modality Positron Emission Tomography/Optical Image-Guided Photodynamic Cancer Therapy with Chlorin e6-Containing Nanomicelles

作者:

Liang Cheng,*,†,‡ Anyanee Kamkaew, Haiyan Sun, Dawei Jiang, Hector F. Valdovinos,§ Hua Gong, Christopher G. England,§ Shreya Goel, Todd E. Barnhart,§ and Weibo Cai*,‡,§,

单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

Department of Radiology,§Department of Medical Physics, andMaterials Science Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States

摘要:

We develop an organic photodynamic therapy (PDT) system based on polyethylene glycol (PEG)-coated nanomicelles conjugated with∼20% chlorin e6 (PEG-Ce6 nanomicelles), which functions as an optical imaging agent, as well as a PDT agent. The formed PEG-Ce6 nanomicelles with the size of∼20 nm were highly stable in various physiological solutions for a long time. Moreover, Ce6 can also be a 64Cu chelating agent for in vivo positron emission tomography (PET). By simply mixing, more than 90% of64Cu was chelator-free labeled on PEG-Ce6 nanomicelles, and they also showed high stability in serum conditions. Both fluorescence imaging and PET imaging revealed that PEG-Ce6 nanomicelles displayed high tumor uptake (13.7 ± 2.2%ID/g) after intravenous injection into tumor-bearing mice at the 48 h time point. In addition, PEG-Ce6 nanomicelles exhibited excellent PDT properties upon laser irradiation, confirming the theranostic properties of PEG-Ce6 nanomicelles for imaging and treatment of cancer. In addition, PDT was not shown to render any appreciable toxicity.

影响因子:

13.334

分区情况:

1

链接:

http://pubs.acs.org/doi/abs/10.1021/acsnano.6b03074

  

  

责任编辑:向丹婷


返回原图
/