刘庄教授课题组在Advanced Functional Materials上发表论文

发布时间:2017-06-20访问量:18设置

题目:

Bottom-Up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image-Guided Photothermal Radiotherapy

作者:

Sida Shen1, Yu Chao1, Ziliang Dong1, Guanglin Wang2, Xuan Yi2, Guosheng Song1, Kai Yang2,Zhuang Liu1, and Liang Cheng*1

单位:

1Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

2School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection,  Soochow University, Suzhou, Jiangsu 215123, China

摘要:

Facile preparation of multifunctional theranostic nanoplatforms with well-controlled morphology and sizes remains an attractive in the area of nanomedicine. Here, a new kind of 2D transition metal dichalcogenide, rhenium disulfide (ReS2) nanosheets, with uniform sizes, strong near-infrared (NIR) light, and strong X-ray attenuation, is successfully synthesized. After surface modification with poly (ethylene glycol) (PEG), the synthesized ReS2-PEG nanosheets are stable in various physiological solutions. In addition to their contrasts in photoacoustic imaging and X-ray computed tomography imaging because of their strong NIR light and X-ray absorptions, respectively, such ReS2-PEG nanosheets can also be tracked under nuclear imaging after chelator-free labeling with radioisotope ions, 99mTc4+. Efficient tumor accumulation of ReS2-PEG nanosheets is then observed after intravenous injection into tumor-bearing mice under triple-modal imaging. The combined in vivo photothermal radiotherapy is further conducted, achieving a remarkable synergistic tumor destruction effect. Finally, no obvious toxicity of ReS2-PEG nanosheets is observed from the treated mice within 30d. This work suggests that such ultrathin ReS2 nanosheets with well-controlled morphology and uniform sizes may be a promising type of multifunctional theranostic agent for remotely triggered cancer combination therapy.

影响因子:

12.124

分区情况:

1

链接:

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201700250/full



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