彭睿教授课题组发表的文章入选“2016 Hot Articles in Nanoscale”

发布时间:2016-03-29访问量:26设置

近日,我院彭睿教授课题组与刘庄教授课题组合作的研究成果“Functionalized graphene oxide serves  as a novel vaccine nano-adjuvant for robust stimulation of cellular  immunity”(第一作者:许利耕)入选“2016 Hot Articles in  Nanoscale”。



文章摘要:

Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. In this study, we carefully engineered graphene oxide (GO) as a  vaccine adjuvant for immunotherapy using urease B (Ure B) as the model antigen.  Ure B is a specific antigen for Helicobacter pylori, which is a class I carcinogen for gastric cancer. Polyethylene glycol (PEG) and various types of polyethylenimine  (PEI) were used as coating polymers. Compared with single-polymer modified GOs  (GO–PEG and GO–PEI), certain dual-polymer modified GOs (GO–PEG–PEI) can act as a  positive modulator to promote the maturation of dendritic cells (DCs) and  enhance their cytokine secretion through the activation of multiple toll-like receptor (TLR) pathways while showing low toxicity. Moreover, this GO–PEG–PEI  can serve as an antigen carrier to effectively shuttle antigens into DCs. These  two advantages enable GO–PEG–PEI to serve as a novel vaccine adjuvant. In the  subsequent in  vivo experiments,  compared with free Ure B and clinically used aluminum-adjuvant-based vaccine (Alum-Ure B), GO–PEG–PEI–Ure B induces stronger cellular immunity  via intradermal administration,  suggesting promising applications in cancer immunotherapy. Our work not only presents a novel, highly effective GO-based vaccine nano-adjuvant, but also highlights the critical roles of surface chemistry for the rational design of  nano-adjuvants.

  

文章链接http://pubs.rsc.org/en/content/articlelanding/2016/nr/c5nr09208f#!divAbstract



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