刘庄教授课题组在 Nano Letters上发表论文

发布时间:2018-09-17访问量:693设置

题目:

Bimetallic Oxide MnMoONanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy

作者:

Fei Gong, Liang Cheng,*, Nailin Yang, Qiutong Jin, Longlong Tian, Mengyun Wang, Yonggang Li, and Zhuang Liu*,

单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China

Department of Radiology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China

摘要:

Accurate imaging of glutathione (GSH) in vivo is able to provide real-time visualization of physiological and pathological conditions. Herein, we successfully synthesize bimetallic oxide MnMoOX nanorods as an intelligent nanoprobe for in vivo GSH detection via photoacoustic (PA) imaging. The obtained MnMoOX nanoprobe with no near-infrared (NIR) absorption in the absence of GSH would exhibit strong GSH-responsive NIR absorbance, endowing PA imaging detection of GSH. Due to the up-regulated GSH concentration in the tumor microenvironment, our MnMoOX nanoprobe could be utilized for in vivo tumor-specific PA imaging. Moreover, MnMoOX nanorods with GSH-responsive NIR absorbance could also be employed to achieve tumor-specific photothermal therapy (PTT). Importantly, such MnMoOX nanorods show inherent biodegradability and could be rapidly cleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy.

影响因子:

12.080

分区情况:

一区

链接:

https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.8b02933



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