Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics
Yuyan Chen, Liang Cheng,* Ziliang Dong, Yu Chao, Huali Lei, He Zhao, Jian Wang, and Zhuang Liu*
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Jiangsu 215123, China
Multifunctional biodegradable inorganic theranostic nano-agents are of great interest to the field of nanomedicine. Upon lipid modification, VS2 nanosheets could be converted into ultra-small VS2 nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to paramagnetism, high near-infrared (NIR) absorbance, and chelator-free99mTc4+ labeling of VS2, such VS2@lipid-PEG nanoparticlescould be used for T1-weighted magnetic resonance (MR),photoacoustic (PA),and single photon emission computedtomography (SPECT) tri-modal imaging guided photothermalablation of tumors. Importantly, along with the gradualdegradation of VS2, our VS2@lipid-PEG nanoparticles exhibiteffective body excretion without appreciable toxicity. Theunique advantages of VS2 nanostructures with highly integrated functionalities and biodegradable behaviors mean they are promising for applications in cancer theranostics.