康振辉教授课题组和上海交通大学医学院、上海微系统与信息技术研究所合作在Advanced Functional Materials上发表论文

发布时间:2018-05-30访问量:67设置

题目:

Emancipating Target-Functionalized Carbon Dots from Autophagy Vesicles for a Novel Visualized Tumor Therapy

作者:

Jipeng Li1, Siwei Yang2, Yuan Deng1, Peiwei Chai1, Yucheng Yang2, Xiaoyu He1, Xiaoming Xie2, Zhenhui Kang,*3 Guqiao Ding,*2 Huifang Zhou,*1 and Xianqun Fan*1

单位:

1 Department of Ophthalmology Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011, China

Center for Excellence in Superconducting Electronics (CENSE) State Key, Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT) Chinese Academy of Science Shanghai 200500, China

3 Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University Suzhou 215123, China

摘要:

Killing the tumor cells by a visualized targeting system is a promising strategy with which to achieve high efficiency, low side effects, and a high survival rate for tumor therapy. Here, an autophagy regulation strategy is reported by emancipating target-functionalized carbon dots from autophagy vesicles for the efficient visualized tumor therapy. The folic acid modified N-doped carbon dots (FN-CDs) are selectively endocytosed (specific cellular uptake rate>93.40%) and stably existed in autophagic vacuoles in tumor cells. Next, the autophagic vacuoles are “opened” by the autophagy inhibitors. Released FN-CDs   activate both the intrinsic and extrinsic apoptotic signaling pathway and kill tumor cells efficiently. This method achieves therapeutic effects with high performance in 26 types of tumor cell lines. Animal experiments show that the 30 d survival rate of this therapeutic strategy is much higher than that with traditional drug treatment. Real-time imaging/monitoring and its effects on the intelligent tumor therapy are also demonstrated based on the stable, strong, green emission from FN-CDs.

影响因子:

12.124

分区情况:

一区

链接:

https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.201800881


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