彭睿教授课题组与刘庄教授课题组合作在ACS Nano上发表论文

发布时间:2018-05-30访问量:86设置

题目:

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

作者:

Rong Yang, Jun Xu, Ligeng   Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng* , and Zhuang Liu*

单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou,   Jiangsu 215123, China.

摘要:

Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we present a strategy to construct cancer vaccines by encapsulating immune-adjuvant nanoparticles with cancer cell membranes modified by mannose. Poly(D,L-lactide-co-glycolide)   nanoparticles are first loaded with toll-like receptor 7 agonist, imiquimod   (R837). Those adjuvant nanoparticles (NP-R) are then coated with cancer cell membranes (NP-R@M), whose surface proteins could act as tumor-specific antigens. With further modification with mannose moiety (NP-R@M-M), the obtained nanovaccine shows enhanced uptake by antigen presenting cells such as dendritic cells, which would then be stimulated to the maturation status to trigger antitumor immune responses. With great efficacy to delay tumor development as a prevention vaccine, vaccination with such NP-R@M-M in combination with checkpoint-blockade therapy further demonstrates outstanding therapeutic efficacy to treat established tumors. Therefore, our work presents an innovative way to fabricate cancer nanovaccines, which in principle may be applied for a wide range of tumor types.

影响因子:

13.942

分区情况:

一区

链接:

https://pubs.acs.org/doi/abs/10.1021%2Facsnano.7b09041%20



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