Prof. Chao Wang’s research paper ”Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy” was published on Science Advances (Sci. Adv.5, eaaw6870, 2019). Prof. Zhen Gu from UCLA, US, and Prof. Zhuang Liu, as co-corresponding authors. Xiao and Shufang in FUNSOM are co-first authors.
Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto the nanoerythrosomes by fusing tumor cell membrane–associated antigens with nanoerythrosomes. This tumor antigen–loaded nanoerythrosomes (nano-Ag@erythrosome) elicited antigen responses in vivo and, in combination with the anti–programmed death ligand 1 (PD-L1) blockade, inhibited the tumor growth in B16F10 and 4T1 tumor models. We also generated a tumor model showing that “personalized nano-Ag@erythrosomes” could be achieved by fusing RBCs and surgically removed tumors, which effectively reduced tumor recurrence and metastasis after surgery.
Link to the paper: https://doi.org/10.1126/sciadv.aaw6870
Editor: Wenchang Zhu