ACS Nano: Chelator-Free Labeling of Metal Oxide Nanostructures with Zirconium-89 for Positron Emission Tomography Imaging

Title：

Chelator-Free Labeling of Metal Oxide Nanostructures with Zirconium-89 for Positron Emission Tomography Imaging

Authors：

Liang Cheng,^*,†,‡ Sida Shen,^† Dawei Jiang,^‡,∥ Qiutong Jin,^† Paul A. Ellison,^‡ Emily B. Ehlerding,^‡Shreya Goel,‡ Guosheng Song,† Peng Huang,∥ Todd E. Barnhart,‡ Zhuang Liu,^*,† and Weibo Cai^*,‡,§

Institutions：

†Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

‡Departments of Radiology and Medical Physics, University of Wisconsin----Madison, Madison, Wisconsin 53705, United States

§University of Wisconsin Carbone Cancer Center, Madison, Wisconsin 53705, United States

∥Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, China

Abstract：

Radiolabeling of molecules or nanoparticles to form imaging probes is critical for positron emission tomography (PET) imaging, which, with high sensitivity and the ability for quantitative imaging, has been widely used in the clinic. While conventional radiolabeling often employs chelator molecules, a general method for chelator-free radiolabeling of a wide range of materials remains to be developed. Herein, we determined   that 10 different types of metal oxide (M_xO_y, M = Gd, Ti, Te, Eu, Ta, Er, Y, Yb, Ce, or Mo, x =1−2, y = 2−5) nanomaterials with polyethylene glycol (PEG) modification could be labeled with ⁸⁹Zr, a PET tracer, via a simple yet general chelator-free radiolabeling method upon simple mixing. High-labeling yields and good serum stabilities are achieved with this method, owing to the strong bonding between oxyphilic ⁸⁹Zr⁴⁺ with oxygen atoms on the MxOy surface. Selecting ⁸⁹Zr−Gd₂O₃−PEG as a multimodal imaging probe, we have successfully demonstrated in vivo PET imaging of draining lymph nodes, which are also visualized under magnetic resonance imaging, showing advantages over free ⁸⁹Zr in the mapping of draining lymph node networks. Our work describes a general and simple method for chelator-free radiolabeling of metal oxide nanostructures, which is promising for the development of multifunctional nanoprobes in biomedical imaging.

IF：

13.942

Link：

http://pubs.acs.org/doi/10.1021/acsnano.7b05428