ACS Nano: Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

time:2018-05-30Hits:325设置

题目:

Cancer Cell Membrane-Coated AdjuvantNanoparticles with Mannose  Modification for Effective Anticancer Vaccination

作者:

Rong Yang1, Jun Xu2, Ligeng Xu3*, Xiaoqi Sun4, Qian Chen5, Yuhuan Zhao6, Rui Peng*2, and Zhuang Liu*1

单位:

1Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nanoscience and Technology, Soochow University, 199 Ren-AiRoad, Suzhou 215123, China.

2Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University.

摘要:

Tumor vaccines for cancer prevention and treatment haveattracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we present a strategy to construct cancer vaccines by encapsulating immune-adjuvant nanoparticles with cancer cell membranes modified by mannose.Poly(D,L-lactide-co-glycolide) nanoparticles are first loaded with toll-like receptor 7 agonist, imiquimod (R837). Those adjuvant nanoparticles (NP-R) are then coated with cancer cell membranes (NP-R@M), whose surface proteins could act as tumor-specific antigens. With further modification with mannose moiety (NP-R@M-M), the obtained nanovaccine shows enhanced uptake by antigen presenting cells such as dendritic cells, which would then be stimulated to the maturation status to trigger antitumor immune responses. With great efficacy to delay tumor development as a prevention vaccine, vaccination with such NP-R@M-M in combination with checkpoint-blockade therapy further demonstrates outstanding therapeutic efficacy to treat established tumors. Therefore, our work presents an innovative way to fabricate cancer nanovaccines, which in principle may be applied for a wide range of tumor types.

影响因子:

13.942

分区情况:

一区

链接:

https://pubs.acs.org/doi/abs/10.1021%2Facsnano.7b09041%20

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