Adv. Mater.: Ultrasmall Oxygen-Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

time:2019-05-09Hits:249设置

Title:

Ultrasmall Oxygen-Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

Authors:

Fei Gong,1 Liang Cheng,*1 Nailin Yang,1 Oshra Betzer,2 Liangzhu Feng,1 Qiang Zhou,3 Yonggang Li,3 Ruihua Chen,3 Rachela Popovtzer,2 and Zhuang Liu*1

Institutions:

1Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for  Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China

2Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 52900, Israel

3Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

Abstract:

Sonodynamic therapy (SDT) triggered by ultrasound (US) has attracted increasing attention owing to its abilities to overcome critical limitations including low tissue-penetration depth and phototoxicity in photodynamic therapy. Herein, the design of a new type of sonosensitizer is revealed, namely, ultrasmall oxygen-deficient bimetallic oxide MnWOX nanoparticles, for multimodal imaging-guided enhanced SDT against cancer. As-made MnWOX nanoparticles with poly(ethylene glycol) (PEG) modification show high physiological stability and biocompatibility. Interestingly, such MnWOX-PEG nanoparticles exhibit highly efficient US-triggered production of 1O2 and •OH, higher than that of previously reported sonosensitizers (e.g., protoporphyrin IX and titanium dioxide), because the oxygen-deficient structure of MnWOX serves as an electron trap site to prevent electron-hole recombination. The glutathione depletion capability of MnWOX-PEG can also further favor SDT-triggered cancer cell killing. With efficient tumor homing as illustrated by computer tomography and magnetic resonance imaging, MnWOX-PEG enables effective destruction of mouse tumors under US stimulation. After accomplishing its therapeutic functions, MnWOX-PEG can be metabolized by the mouse body without any long-term toxicity. Herein, a new type of sono-sensitizing agent with high SDT efficacy, multimodal imaging functions, and rapid clearance is presented, an agent which is promising for noninvasive SDT cancer treatment.

IF:

21.95

Link:

https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201900730



Editor:Wenchang Zhu

  


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