Nanobiotechnology & Nanomedicine

Nanobiotechnology & Nanomedicine

Nanobiotechnology & Nanomedicine is a rapidly advancing interdisciplinary field that bridges physical sciences with biology and medicine via chemistry tools. The nanomedicine laboratories in FUNSOM have been conducting cutting edge research to develop novel functional nanomaterials with excellent biocompatibility and unique optical/electrical/magnetic properties for applications in biological and biomedical research.

Research directions:

1. Nanomedicine and cancer therapy

We are developing functional nanomaterials with high biocompatibility, low toxicity, and immunogenicity as efficient safe nano-carriers for drug delivery and gene therapy. We are investigating physical methods-assisted tumor targeting and therapies by taking advantage of novel properties of these functional nanomaterials.

2. Nano-biosensors and biochip technologies

In personalized medicine, it is critical to develop techniques enabling early diagnosis of tumors and other serious diseases that require highly sensitive and robust methods of detection. We have been working on integrated biochips and functional nanomaterials for synergistic enhancement in analysis and diagnosis of disease biomarkers, with applications in translational biomedical research.

3. Nano-probes and bioimaging

We are developing functional nanomaterials (e.g., quantum dots, silicon nanospheres, and upconversion nanoparticles) and their bioconjugates (with proteins and DNAs/RNAs), as novel fluorescent  and photoacoustic probes for high-quality molecular imaging and therefore, providing new materials and methods for research in molecular and cellular biology.

4. Polymeric biomaterials and drug delivery systems

We are developing multifunctional polymeric biomaterials and construct smart delivery vehicles for macromolecular drugs, such as proteins, peptides, nucleic acids, etc., and attempting to achieve targeted, controlled, and effective delivery of these drug cargoes. We are investigating novel strategies towards the treatment of cancer and inflammation by utilizing polymeric delivery systems.

5. Biological effects and biosafety issues of nanomaterials

We are enhancing the mechanisms and interactions between nanomaterials and biological molecules, cells, as well as biological systems. We are carrying out biosafety assessment of primary biomedical nanomaterials in vitro and in vivo systematically.

Editor: Danting Xiang