刘庄教授、冯良珠副研究员合作在Nat. Commun.上发表论文

题目：

Tumor-killing Nanoreactors Fueled by Tumor Debris Can Enhance Radiofrequency Ablation Therapy and Boost Antitumor Immune Responses

作者：

Zhijuan Yang¹, Yujie Zhu¹, Ziliang Dong¹, Wei Li¹, Nailin Yang¹, Xianwen Wang¹, Liangzhu Feng ^1,* & Zhuang Liu^1,2,*

单位：

¹Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, PR China

²Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Taipa, Macau, PR China

摘要：

Radiofrequency ablation (RFA) is clinically adopted to destruct solid tumors, but is often incapable of completely ablating large tumors and those with multiple metastatic sites. Here we develop a CaCO₃-assisted double emulsion method to encapsulate lipoxidase and hemin with poly(lactic-co-glycolic acid) (PLGA) to enhance RFA. We show the HLCaP nanoreactors (NRs) with pH-dependent catalytic capacity can continuously produce cytotoxic lipid radicals via the lipid peroxidation chain reaction using cancer cell debris as the fuel. Upon being fixed inside the residual tumors post RFA, HLCaP NRs exhibit a suppression effect on residual tumors in mice and rabbits by triggering ferroptosis. Moreover, treatment with HLCaP NRs post RFA can prime antitumor immunity to effectively suppress the growth of both residual and metastatic tumors, also in combination with immune checkpoint blockade. This work highlights that tumor-debris-fueled nanoreactors can benefit RFA by inhibiting tumor recurrence and preventing tumor metastasis.

影响因子：

14.92

分区情况：

一区

链接：

https://www.nature.com/articles/s41467-021-24604-9