Adv. Mater.: 3D Printing Scaffold Vaccine for Antitumor Immunity

Title：

3D Printing Scaffold Vaccine for Antitumor Immunity

Authors：

Yue Zhang, Jialu Xu, Ziying Fei, Huaxing Dai, Qin Fan, Qianyu Yang, Yitong Chen, Beilei Wang, Chao Wang*

Institutions：

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China

Abstract：

Cancer vaccine platform has attracted great interest in the field of cancer immunotherapy. Here, we developed a 3D printed scaffolds loaded with immunoregulators for enhanced cancer immunotherapy. The rapid manufacturing and precise molding based on 3D printing can realize the mass manufacturing of cancer vaccines and personalized design. Meanwhile, compared to the traditional hydrogel, the 3D-scaffold with porous structure endowed it similar functions compared with real lymphoid organs by recruitment of a great number of immune cells, leading to the formation of ‘artificial tertiary lymphoid structures (aTLS)’, where is a promising site to enhance both humoral and cellular immune responses. Efficient anticancer immunity is induced when combined with immune checkpoint blockade (ICB) to inhibit the tumor growth. We further demonstrate personalized anti-tumor scaffold vaccines for filling of tumor site after surgery to prevent cancer metastasis. Taken together, these results promise the 3D printing scaffold vaccine as the potential strategy for cancer vaccine therapy in the future.

If：

27.398

Link：

https://doi.org/10.1002/adma.202106768