Adv. Mater.: Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Title:

Intelligent Albumin-MnO₂ Nanoparticles as pH-/H₂O₂-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Authors:

Qian Chen, Liangzhu Feng, Jingjing Liu, Wenwen Zhu, Ziliang Dong, Yifan Wu, Zhuang Liu*

Institution:

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, P. R. China

Abstract:

A unique type of pH/H₂O₂ dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO₂ is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

IF:

18.960

Link:

http://onlinelibrary.wiley.com/doi/10.1002/adma.201601902/full