Adv. Mater.: Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

Title:

Catalase-Loaded TaO_x Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

Authors:

Guosheng Song, Yuyan Chen, Chao Liang, Xuan Yi, Jingjing Liu, Xiaoqi Sun, Sida Shen, Kai Yang, and Zhuang Liu*

Institutions:

Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, P. R. China

School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X) Medical College of Soochow University Suzhou, Jiangsu 215123, P. R. China

Abstract:

A novel type of bio-nanoreactor with catalase loaded inside TaO_x hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H₂O₂ in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.

IF:

18.960

Link:

http://onlinelibrary.wiley.com/doi/10.1002/adma.201602111/full