Title: | Dual-Modality Positron Emission Tomography/Optical Image-Guided Photodynamic Cancer Therapy with Chlorin e6-Containing Nanomicelles |
Liang Cheng,*,†,‡ Anyanee Kamkaew,‡ Haiyan Sun,‡ Dawei Jiang,‡ Hector F. Valdovinos,§ Hua Gong,† Christopher G. England,§ Shreya Goel,∥ Todd E. Barnhart,§ and Weibo Cai*,‡,§,∥ | |
Institutions: | †Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China ‡Department of Radiology,§Department of Medical Physics, and∥Materials Science Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States |
| Abstract: | We develop an organic photodynamic therapy (PDT) system based on polyethylene glycol (PEG)-coated nanomicelles conjugated with ~20% chlorin e6 (PEG-Ce6 nanomicelles), which functions as an optical imaging agent, as well as a PDT agent. The formed PEG-Ce6 nanomicelles with the size of ~20 nm were highly stable in various physiological solutions for a long time. Moreover, Ce6 can also be a 64Cu chelating agent for in vivo positron emission tomography (PET). By simply mixing, more than 90% of64Cu was chelator-free labeled on PEG-Ce6 nanomicelles, and they also showed high stability in serum conditions. Both fluorescence imaging and PET imaging revealed that PEG-Ce6 nanomicelles displayed high tumor uptake (13.7 ± 2.2%ID/g) after intravenous injection into tumor-bearing mice at the 48 h time point. In addition, PEG-Ce6 nanomicelles exhibited excellent PDT properties upon laser irradiation, confirming the theranostic properties of PEG-Ce6 nanomicelles for imaging and treatment of cancer. In addition, PDT was not shown to render any appreciable toxicity. |
IF: | 13.334 |
Editor: Danting Xiang