Adv. Mater.: Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

Title:

Perfluorocarbon-Loaded Hollow Bi₂Se₃ Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

Authors:

Guosheng Song, Chao Liang, Xuan Yi, Qi Zhao, Liang Cheng, Kai Yang, and Zhuang Liu*

Institutions:

Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University, Suzhou, Jiangsu 215123, China

School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X) Medical College of Soochow University, Suzhou, Jiangsu 215123, China

Abstract:

Hollow Bi₂Se₃ nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X-ray-absorbing ability to locally concentrate radiation energy in the tumor, but also employing near-infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia-associated radio-resistance.

IF:

17.493

Link:

http://onlinelibrary.wiley.com/doi/10.1002/adma.201504617/full

Editor: Danting Xiang