葛成龙 副研究员

发布时间：2024-10-31访问量：615设置




葛成龙 副研究员


教育经历

2018/09-2021/06：苏州大学，功能纳米与软物质研究院，化学，理学博士

2015/09-2018/06：湘潭大学，化学学院，化学，理学硕士

2011/09-2015/06：湘潭大学，化学学院，高分子材料与工程，工学学士


工作经历

2024/10-至今：苏州大学，功能纳米与软物质研究院，副研究员

2021/07-2024/06：苏州大学，功能纳米与软物质研究院，博士后


所在课题组

殷黎晨教授课题组


主持项目

1.  国家自然科学基金委员会，青年基金项目（主持）

2.  江苏省科技厅，自然科学青年基金项目（主持）

3.  中国博士后科学基金会，第72批面上资助（主持）


研究领域

1.  聚多肽的可控开环聚合及聚合方法学

2.  功能化聚多肽的二级结构调控及生物学效应

3.  高分子递送载体在基因、药物及蛋白跨屏障递送中的研究


代表性研究成果

截止目前，共参与发表SCI论文30多篇，其中以第一作者或通讯作者身份在J Am Chem Soc、Nano Lett、Chin J Chem、Biomacromolecules、J Mater Chem B等期刊发表论文12篇。


代表性论文

  1. Fan Zhang#, Chenglong Ge#, Zigang Qiao, Yu Han, Lichen Yin*, Feng Ma*. Protocol for siRNA-mediated U1 snRNA Knockdown using Fluorinated α-Helical Polypeptide In vitro and In vivo.STAR Protocols, 2024, 5, 103238.

  2. Chenglong Ge#, Jianyin He#, Mudan, Gan#, Yu Qian, Junliang Zhu, Fan Wu, Ziyuan Song*, Lichen Yin*. Conformation-Switchable Polypeptides as Molecular Gates for Controllable Drug Release. Biomacromolecules, 2024, 25, 3373-3383.

  3. Chenglong Ge, Junliang Zhu, Huan Ye, Yuansong Wei, Yuheng Lei, Renxiang Zhou, Ziyuan Song, Lichen Yin*. Rational Construction of Protein-mimetic Nano-switch System Based on Secondary Structure Transition of Synthetic Polypeptide. J Am Chem Soc, 2023, 145, 11206-11214.

  4. Junliang Zhu#, Yunjie He#, Chenglong Ge*, Wenting Si, Ziyuan Song*, Lichen Yin*. Accelerated Ring-opening Polymerization of α-Amino Acid N-carboxyanhydride via Inorganic Nano-initiators. Chin J Chem, 2023, 41, 2476-2482.

  5. Chenglong Ge#, Junliang Zhu#, Guangqi Wu, Huan Ye, Hua Lu*, Lichen Yin*. ROS-Responsive Selenopolypeptide Micelles: Preparation, Characterization, and Controlled Drug Release. Biomacromolecules, 2022, 23, 2647-2654.

  6. Chenglong Ge, Yong Liu, Lichen Yin*. Effect and Regulation of the Secondary Structure of Synthetic Poly(α-amino acid) based on Ring-opening Polymerization. Chin Sci Bull, 2021, 66, 2217-2230.

  7. Chenglong Ge, Huan Ye, Fan Wu, Junliang Zhu, Ziyuan Song, Yong Liu,* Lichen Yin*. Biological Applications of Water-Soluble Polypeptides with Ordered Secondary Structures. J Mater Chem B, 2020, 8, 6530-6547.

  8. Chenglong Ge#, Jiandong Yang#, Shanzhou Duan, Yong Liu, Fenghua Meng, Lichen Yin*. Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration Toward Highly Efficient Pulmonary siRNA Delivery Against Acute Lung Injury. Nano Lett, 2020, 20, 1738-1746.

  9. Chenglong Ge, Ying Ling*, Shunjie Yan, Shifang Luan, Haowen Zhang, Haoyu Tang*. Preparation and Mechanical Properties of Strong and Tough Poly(vinyl alcohol)-Polypeptide Double-Network Hydrogels. Eur Polym J, 2018, 99, 504-510.

  10. Chenglong Ge, Wenjun Liu, Ying Ling*, Haoyu Tang*. Synthesis and Thermoresponsive Properties of OEGylated Polypeptide with a LCST at Body Temperature in Water and with a UCST in Alcohol or Ethanol/Water Solvent Mixture. J Polym Sci, Part A: Polym Chem, 2018, 56, 163-173.

  11. Chenglong Ge, Liang Zhao, Ying Ling*, Haoyu Tang*. Thermo and pH Dual Responsive Polypeptides Derived from “Clickable” Poly(γ-3-methylthiopropyl-L-glutamate). Polym Chem, 2017, 8, 1895-1905.

  12. Chenglong Ge, Sheng Liu, Ce Liang, Ying Ling*, Haoyu Tang*. Synthesis and UCST-type Phase Behavior of α-Helical Polypeptides with Y-shaped and Imidazolium Pendants. Polym Chem, 2016, 7, 5978-5987.


参与编写书籍

  1. Chenglong Ge, Xun Liu, Lichen Yin. Gene Delivery (chapter 4), in “Biomaterial Engineering, Fluorinated α-Helical Polypeptides Toward Pulmonary siRNA Delivery”. Springer Nature, edited by Youqing Shen, Huayu Tian, Xuesi Chen. pp 75-96.

 

责任编辑：杨娟


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