殷黎晨 教授

发布时间:2013-02-27访问量:9662设置


殷黎晨

教授 博士生导师


        20057月获复旦大学生物科学专业学士学位;20107月获复旦大学生物化学与分子生物学专业博士学位。201011月至20141月在美国伊利诺伊大学香槟分校(UIUC)材料科学与工程系从事博士后研究工作。20141月加盟苏州大学功能纳米与软物质研究院,被聘为特聘教授、博士生导师。


邮箱:lcyin@suda.edu.cn

电话:0512-65882039

  

个人介绍:

主要从事生物医用高分子和药物递送系统的开发并研究其在肿瘤、炎症、自身免疫性疾病治疗中的应用。共发表SCI论文100余篇(第一作者、通讯作者论文70余篇,影响因子大于10的论文28篇),他引5000余次,H因子387篇论文入选ESI高被引论文。获中国发明专利6项,美国专利2项。为欧美权威教材《Biomaterials Science》第四版撰写章节Nanoparticles。应邀担任第258届美国化学会年会分会场共同主席,Adv Drug Deliver Rev客座编辑。获国家优秀青年科学基金资助,入选江苏省特聘教授(重点资助)、江苏省双创人才。主持国家重点研发计划课题1项、国家自然科学基金4项。担任Nat CommunSci AdvJACSAdv MaterAdv Funct MaterACS Nano20余个期刊的独立审稿人。

  

研究方向:

1)聚氨基酸生物材料:研究可用于药物载体、基因载体、免疫调节剂的聚氨基酸的合成与功能化修饰,探讨聚氨基酸的二级结构效应和调控方式。

2)智能化药物递送系统:研究可改善蛋白质、多肽、核酸、小分子化学药物、气体分子等功效的新型给药载体的加工、改性、组装、体内外作用机理及其给药系统的设计。

3抗炎治疗与抗肿瘤治疗:根据疾病的发病机制及病灶部位的生理特点,设计新型纳米药物调控肿瘤、炎症等免疫微环境,用于肿瘤、炎症(如肝炎、胰腺炎、心肌梗死、急性肺损伤、脑卒中、骨性关节炎等)、自身免疫性疾病(如溃疡性结肠炎、类风湿性关节炎、系统性红斑狼疮等)的治疗。

  

招生方向:

本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生和博士研究生加盟。本课题组的研究为交叉学科,招生方向包括化学生物学以及材料学,欢迎具有化学、材料或生物背景的同学报考。如有咨询,请联系lcyin@suda.edu.cn

  

招聘信息:

博士后拟招收3-5名从事高分子生物材料合成、纳米药物设计、基因药物递送研究的博士后研究人员,要求能够独立开展研究工作,具有良好的英文写作与交流能力;易于沟通,可以协助指导研究生。具有高分子化学、有机化学、生物材料或药剂学背景的申请者优先考虑。待遇优厚,且有机会到国外交流访学。如有兴趣,请联系lcyin@suda.edu.cn

讲师/副教授拟招聘1-2名课题组讲师/副教授,要求获得(或即将获得)博士学位,具有高分子化学、生物材料或药剂学背景,在主流期刊上发表过SCI论文,能够独立开展研究并指导研究生。有意向者请发送简历和三位推荐人信息至lcyin@suda.edu.cn

  

近五年代表性论文(*为通讯作者,#为共同第一作者):

1.   Xudong Li#, Yuansong Wei#, Yuchen Wu, Lichen Yin*. Hypoxia-instructed pro-protein therapy assisted with self-catalyzed nanozymogen. Angew Chem Int Ed, 2020, doi:10.1002/anie.202004008.

2.   Shixian Lv, Hojun Kim, Ziyuan Song, Feng Lin, Yingfeng Yang, Ryan Baumgartner, Kuan-Ying Tseng, Shen J. Dillon, Cecilia Leal, Lichen Yin*, Jianjun Cheng*. Unimolecular polypeptide micelles via ultra-fast polymerization of N-carboxyanhydrides. J Am Chem Soc, 2020, 142, 8570-8574.

3.   Chenglong Ge#, Jiandong Yang#, Shanzhou Duan, Yong Liu, Fenghua Meng, Lichen Yin*. Fluorinated α-helical polypeptides synchronize mucus permeation and cell penetration toward highly efficient pulmonary siRNA delivery against acute lung injury. Nano Lett, 2020, 20, 1738−1746.

4.   Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou*, Mengying Hou, Xudong Li, Yong Liu*, Lichen Yin*. Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters. Biomaterials, 2020, 255, 120166.

5.   Jing Yan, Rongying Zhu, Fan Wu, Ziyin Zhao, Huan Ye, Mengying Hou, Yong Liu*, Lichen Yin*. iRGD-Reinforced, Photo-Transformable Nanoclusters Toward Cooperative Enhancement of Intratumoral Penetration and Antitumor Efficacy. Nano Res, 2020, 13, 2706-2715.

6.   Xiao Wang#, Qiujun Liang#, Yiming Mao, Rujing Zhang, Qiurong Deng, Yongbing Chen*, Rongying Zhu, Shanzhou Duan, Lichen Yin*. Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury.Biomater Sci, 2020, 8, 3856-3870.

7.   Yongjuan Li, Juanjuan Dang, Qiujun Liang, Lichen Yin*. Thermal-responsive carbon monoxide (CO) delivery expedites metabolic exhaustion of cancer cells toward reversal of chemotherapy resistance.ACS Cent Sci, 2019, 5, 1044−1058.

8.   Yongjuan Li#, Juanjuan Dang#, Qiujun Liang, Lichen Yin*. Carbon monoxide (CO)-strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction. Biomaterials, 2019, 209, 138-151.

9.   Juanjuan Dang, Huan Ye, Yongjuan Li, Qiujun Liang, Xudong Li, Lichen Yin*. Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism. Biomaterials, 2019, 223, 119463.

10.Yongjuan Li, Jian Hu, Xun Liu, Yong Liu*, Shixian Lv, Juanjuan Dang, Yong Ji*, Jinlin He, Lichen Yin*. Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment. Nano Res, 2019, 12, 999-1008.

11.Xin Xu#, Weijing Yang#, Qiujun Liang, Yanan Shi, Wenxin Zhang, Xiao Wang, Fenghua Meng, Zhiyuan Zhong*, Lichen Yin*. Efficient and Targeted Drug/siRNA Co-Delivery Mediated by Reversibly Crosslinked Polymersomes toward Anti-Inflammatory Treatment of Ulcerative Colitis (UC). Nano Res, 2019, 12, 659-667.

12.Jinhui Wang#, Hua He#, Xin Xu, Xiao Wang, Yongbing Chen, Lichen Yin*. Far-Red Light-Mediated Programmable Anti-Cancer Gene Delivery in Cooperation with Photodynamic Therapy. Biomaterials, 2018, 171, 72-82.

13.Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li,Min Lan, Xuesi Chen, Jianjun Cheng,Lichen Yin*. High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor−Receptor Coordination Interactions. J Am Chem Soc, 2018, 140, 1235−1238.

14.Hong-Xia Wang, Ziyuan Song, Yeh-Hsing Lao, Xin Xu, Jing Gong, Du Cheng, Syandan Chakraborty, Mingqiang Li, Dangtong Huang, Lichen Yin*, Jianjun Cheng*, Kam W. Leong*. Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide. Proc Natl Acad Sci USA, 2018, 115, 4903-4908.

15.Hua He#, Yongbing Chen#, Yongjuan Li#, Ziyuan Song, Yinan Zhong, Rongying Zhu, Jianjun Cheng*,Lichen Yin*. Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering. Adv Funct Mater, 2018, 28, 1706710.

16.Hua Wang#, Ruibo Wang#, Kaimin Cai#, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*, Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting. Nat Chem Biol, 2017, 13, 415-424.

17.Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*, Lichen Yin*, Jianjun Cheng*. Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands. Nat Commun, 2017, 8:92.

18.Menghua Xiong#, Yan Bao#, Xin Xu#, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M. Peek, Lichen Yin*, Lin-Feng Chen*, Jianjun Cheng*. Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides. Proc Natl Acad Sci USA, 2017, 114, 12675-12680.

19.Menghua Xiong, Zhiyuan Han, Ziyuan Song, Jin Yu, Hanze Ying, Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition. Angew Chem Int Ed, 2017, 56, 10826-10829.

20.Hua He, Nan Zheng, Ziyuan Song, Kyung Hoon Kim, Catherine Yao, Rujing Zhang, Chenglin Zhang, Yuhui Huang, Fatih M. Uckun, Jianjun Cheng, Yanfeng Zhang, Lichen Yin*. Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles. ACS Nano, 2016, 10, 1859−1870.

 

文章完整列表:https://scholar.google.com/citations?user=66CEhX8AAAAJ&hl=zh-CN


责任编辑:杨娟

返回原图
/