题目： | Unimolecular Polypeptide Micelles via Ultrafast Polymerization of N-Carboxyanhydrides |
作者： | Shixian Lv,1,2 Hojun Kim,1,3 Ziyuan Song,1 Lin Feng,1 Yingfeng Yang,1 Ryan Baumgartner,1 Kuan-Ying Tseng,1 Shen J. Dillon,1 Cecilia Leal,1 Lichen Yin2,* and Jianjun Cheng1,* |
单位： | 1Department of Materials Science and Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States. 2Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China. 3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea. |
摘要： | Polypeptide micelles are widely used as biocompatible nanoplatforms but often suffer from their poor structural stability. Unimolecular polypeptide micelles can effectively address the structure instability issue, but their synthesis with uniform structure and well-controlled and desired sizes remains challenging. Herein we report the convenient preparation of spherical unimolecular micelles through dendritic polyamine-initiated ultrafast ring-opening polymerization of N-carboxyanhydrides (NCAs). Synthetic polypeptides with exceptionally high molecular weights (up to 85 MDa) and low dispersity (Đ<1.05) can be readily obtained, which are the biggest synthetic polypeptides ever reported. The degree of polymerization was controlled in a vast range (25−3200), giving access to nearly monodisperse unimolecular micelles with predictable sizes. Many NCA monomers can be polymerized using this ultrafast polymerization method, which enables the incorporation of various structural and functional moieties into the unimolecular micelles. Because of the simplicity of the synthesis and superior control over the structure, the unimolecular polypeptide micelles may find applications in nanomedicine, supermolecular chemistry, and bionanotechnology. |
影响因子： | 14.695 |
分区情况： | 一区 |
链接： | https://pubs.acs.org/doi/10.1021/jacs.0c01173?ref=pdf 责任编辑：向丹婷 |