题目： | Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer-Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation | |
作者： | Guangzhi Li,1,2,3Shupeng Wang,1,4 Dashi Deng,2 Zhisheng Xiao,1 Ziliang Dong,1 Zhiping Wang,6 Qifang Lei,2,3 Shan Gao,2 Guixiao Huang,2 Enpu Zhang,2 Guohua Zeng,5 Zhong Wen,5 Song Wu2,6,* and Zhuang Liu1,* | |
单位： | 1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China 2Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, China 3Department of Nephrology, The Second Hospital and Center for Renal Diseases, Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China 4School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China 5Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China 6Department of Urology, The Second Hospital of Lanzhou University, Lanzhou 730030, China | |
摘要： | Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for site-specific treatment of tumors with great depth penetration. The design of nano-sonosensitizers suitable for SDT treatment of bladder cancer (BCa) post-intravesical instillation has not yet been reported. Herein, a transmucosal oxygen-self-production SDT nanoplatform is developed to achieve highly efficient SDT against BCa. In this system, fluorinated chitosan (FCS) is synthesized as a highly effective nontoxic transmucosal delivery carrier to assemble with meso-tetra(4-carboxyphenyl)porphineconjugated catalase (CAT-TCPP). The formed CAT-TCPP/FCS nanoparticles after intravesical instillation into the bladder cavity exhibit excellent transmucosal and intratumoral penetration capacities and could efficiently relieve hypoxia in tumor tissues by the catalase-catalyzed O2 generation from tumor endogenous H2O2 to further improve the therapeutic efficacy of SDT to ablate orthotopic bladder tumors under ultrasound. Our work presents a nano-sonosensitizer formulation with FCS to enhance transmucosal delivery and intratumoral diffusion and CAT to improve tumor oxygenation, promising for instillation-based SDT to treat bladder tumors without the concern of systemic toxicity. | |
影响因子： | 13.903 | |
分区情况： | 一区 | |
链接： | https://pubs.acs.org/doi/abs/10.1021/acsnano.9b06689 责任编辑：向丹婷 |