题目： | 3D printed spiral tube–like cellulose scaffold for oral delivery of probiotics |
作者： | Yue Zhang1, Chenmeng Zhou1, Bo Tian2, Jialu Xu1, Xiaoyu Wang1, Huaxing Dai1, Heng Wang1, Fang Xu1, Chao Wang1* |
单位： | 1Laboratory for Biomaterial and immunoengineering, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China. 2The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, China. |
摘要： | Introducing specific strains of probiotics into the gut microbiome is a promising way to modulate the intestinal microbiome to treat various health conditions clinically. However, oral probiotics typically have a temporary or limited impact on the gut microbiome and overall health benefits. Here, we reported a 3D printed cellulose-derived spiral tube-like scaffold that enabled high efficacy of the oral delivery of probiotics. Benefiting from the unique surface pattern, this system can effectively extend the retention time of loaded probiotics in the gut without invading nearby tissues, provide a favorable environment for the survival and long-term colonization of loaded probiotics, and influence the intestinal ecosystem as a dietary fiber after degradation. We demonstrate Roseburia intestinalis-loaded scaffold exerts noticeable impacts on the regulation of the gut microbiome to treat various gut-related diseases, including obesity and inflammatory bowel disease; thus, we provide a universal platform for oral delivery of probiotics. |
影响因子： | 11.7 |
分区情况： | 一区 |
链接： | https://www.science.org/doi/10.1126/sciadv.adp3654 责任编辑：杜欣 |