董彬教授及其合作者在Adv. Mater.上发表论文

作者：

Jiwei Jiang^1#, Jing Hu^2#, Mingtong Li^3#, Mingzhi Luo⁵, Bin Dong¹*, Metin Sitti^3,4*, Xiaohui Yan²*

单位：

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China

²State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen 361005, China

³Physical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569 Stuttgart, Germany

⁴School of Medicine and College of Engineering, Koç University, 34450 Istanbul, Turkey

⁵Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, and School of Medical and Health Engineering, Changzhou University, Changzhou, Jiangsu, China

摘要：

Peritumoral subcutaneous injection has been highly envisioned as an efficient yet low-risk administration of photothermal agents for superficial tumor photothermal therapy. However, obstructed by complex subcutaneous tissue, the delivery of injected photothermal agents to the specific tumor remains a critical issue. Herein, the study reports a polydopamine (PDA)-encapsulated spherical core/shell nanomotor with fluorescent indocyanine green (ICG) immobilized on its PDA shell. Upon the first near-infrared (NIR-I) irradiation, this motor can generate favorable photothermal heat, and meantime, emit a robust ICG fluorescence in the second near-infrared window (NIR-II). The heat turns the motor into an active photothermal agent able to perform thermophoretic propulsion along the irradiation direction in subcutaneous tissue, while the ICG fluorescence can direct the subcutaneous propulsion of motors toward specific tumor through real-time NIR-II imaging. These functions endow the motor with the ability of moving to tumor after being injected at peritumoral site, enabling an enhanced photothermal therapy (PTT). The results demonstrated herein suggest an integrated nanorobotic tool for the superficial PTT using peritumoral administration, highlighting an NIR-II imaging-directed subcutaneous propulsion.

影响因子：

27.4

分区情况：

一区

链接：

https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202417440