程亮教授课题组及其合作者在Nat. Commun.上发表论文

作者：

Shunyi Lu^1,2#, Jie Cao^2#, Zhuorun Song^1,2#, Fei Gong^2#, Peng Yang¹, Jun Ge^1,2, Yunfei He³, Zhihui Han², Guanghui Hou², Zimin Zhang¹, Yuqi Yang², Yun Teng¹, Zengli Zhang⁴, Jun Zou¹*, Liang Cheng²* and Huilin Yang¹*

单位：

¹Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China

²Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China

³The First Affiliated Hospital of Soochow University, Suzhou, 215123, China

⁴Department of Environmental Health School of Public Health, Soochow University, Suzhou, 215123, China

摘要：

The treatment of osteoporosis and related bone defects remains challenging. This study identifies pyroptosis-driven inflammation as a key disruptor of bone homeostasis. To address this, we develop a magnesium-gelatin composite microsphere scaffold (GelMa/Mg/DMF MS) that exploit pyroptosis blockade and hydrogen-mediated inflammation regulation for osteoporosis treatment. This porous microsphere scaffold is implanted into bone defects to achieve the sustained release of hydrogen gas, magnesium ions (Mg²⁺), and dimethyl fumarate (DMF). DMF act by activating the nuclear factor erythroid-related factor 2 to prevent osteoblast pyroptosis, and combine with the antioxidant effects of hydrogen, effectively remodel the inflammatory microenvironment and create favorable conditions for the restoration of bone homeostasis. Mg²⁺ further expedite bone tissue repair. These results demonstrate that the GelMa/Mg/DMF MS effectively reverse inflammatory microenvironments both in vivo and in vitro, resulting in significant tissue repair. These results suggest the combination of hydrogen therapy and pyroptosis blockade as a potential therapeutic strategy.

影响因子：

15.7

分区情况：

一区

链接：

https://doi.org/10.1038/s41467-025-63456-5