冯良珠教授与刘庄教授合作在Adv. Funct. Mater.上发表论文

作者：

Zhijuan Yang^1#, Chunjie Wang^1#, Weihao Yang², Yujie Zhu¹, Yifan Yan¹, Ziliang Dong¹, Zhuang Liu¹*, Liangzhu Feng¹*

单位：

¹Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, PR China.

²Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

摘要：

Active initiation of plasma membrane rupture represents a promising strategy to disrupt cellular homeostasis and induce cancer cell death. This study proposes phospholipase A1 (PLA1) as a molecular “cell-puncher” to hydrolyze phospholipids, compromising cancer cell membrane integrity and enabling uncontrolled molecular flux. PLA1 synergistically enhances the tumoradical efficacy of cholesterol oxidases (CODs) and lipoxygenases (LOXs) by liberating their respective substrates, cholesterol, and polyunsaturated fatty acids. When localized within tumors using a thermoresponsive chitosan/β-glycerol-phosphate hydrogel, PLA1-COD or PLA-LOX enzymatic pairs achieved effective treatment of CT26 murine tumors through cascading plasma membrane rupture and oxidative stress amplification. Furthermore, the hydrogel-embedded enzyme system functioned as an injectable embolic agent, suppressing orthotopic N1S1 hepatoma in rats via transcatheter arterial enzyme embolization. This work demonstrated an enzyme-based oncolytic strategy that targets membrane integrity and oxidative stress pathways, showing significant potential for clinical translation in solid tumor management.

影响因子：

19.0

分区情况：

一区

链接：

https://doi.org/10.1002/adfm.202524124