殷黎晨教授及其合作者在 Adv. Funct. Mater.上发表论文

作者：

Yang Zhou¹,Zhiyong Liu¹, Mengyuan Yin¹, Chenglong Ge¹, Zhongmin Liu¹, Renxiang Zhou ¹, Duanmin Hu²*, Lichen Yin¹*

单位：

¹Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

²Department of Gastroenterology, The Second Affiliated Hospital, Soochow University, Suzhou 215004, China.

摘要：

In autoimmune diseases (AIDs), the interplay of various inflammatory mediators, including cell-free DNA (cfDNA), reactive oxygen species (ROS), and pro-inflammatory cytokines, contributes to a self-amplified inflammatory cascade that greatly limits the efficacy of existing single-target therapies. Herein, biomimetic nanoparticles (NPs) with reversible macrophage membrane (RM) cloaking are developed to scavenge multiple inflammatory mediators for the multifaceted immunomodulation against AIDs. The NPs are constructed by adsorbing catalase (CAT) onto the cationic, spherical polypeptide (GP), followed by surface coating with RM. Because of the RM coating, the NPs feature long blood circulation and efficient inflammation homing after systemic administration. In the inflamed tissues, RM neutralizes multiple pro-inflammatory cytokines and CAT decomposes H₂O₂ to alleviate the oxidative stress. Meanwhile, the O₂ bubbles generated from H₂O₂ decomposition propels shedding of RM, thus exposing inner GP to mediate robust cfDNA scavenging. Consequently, the NPs effectively alleviate inflammation and facilitate tissue repair in mouse models of AIDs including rheumatoid arthritis and inflammatory bowel disease. This study reports a bio-inspired strategy for the multi-target interruption of the self-amplified inflammatory cascade, and renders promising implications for the clinical management of AIDs.

影响因子：

19.0

分区情况：

一区

链接：

https://doi.org/10.1002/adfm.202514713