汪超教授、吴玉敏副研究员及其合作者在Nature Aging上发表论文

作者：

Huaxing Dai¹, Rong Sun¹, Bowen Xie², Fang Xu¹, Xiaoyu Yu¹, Chenhui Weng¹, Chenlu Yao¹, Heng Wang¹, Bingbing Wu¹, Jialu Xu¹, Yue Zhang¹, Bo Tian¹, Xiaolin Shi³, Yumin Wu¹, Ye Liu^2,4,5 & Chao Wang^1,6,7

单位：

¹Laboratory for Biomaterial and Immunoengineering, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, China.

²Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.

³Medical College of Soochow University, Suzhou, China.

⁴State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China.

⁵Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. ⁶Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.

⁷College of Life Sciences, Soochow University, Suzhou, China.

摘要：

Aging impairs immune function and reduces vaccine efficacy, but whether dendritic cells (DCs), which play a central role in initiating immune responses via antigen presentation, contribute to this decline remains unclear. Through single-cell RNA sequencing analysis of lymph node changes upon vaccination in young versus aged mice, here we identify defects in DC migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicate these defects in the diminished vaccine response observed in aging. Furthermore, we demonstrate that oral delivery of yeast-derived nanoparticles elevates expression of the chemokine receptor CCR7 in gut dendritic cells, facilitates their trafficking to lymph nodes in response to chemotactic signals after immunization, and thus enhances vaccine-induced immunity in aged animals. These findings reveal a key mechanism of immune decline in aging and offer a noninvasive strategy to improve dendritic cell function and vaccine efficacy in aging.

影响因子：

17.0

分区情况：

一区

链接：

https://doi.org/10.1038/s43587-026-01068-4