题目： | Near-Infrared-Triggered in situ Gelation System for Repeatedly Enhanced Photothermal-Brachytherapy with a Single Dose |
作者： | Zhouqi Meng†, Yu Chao†, Xuanfang Zhou†, Chao Liang†, Jingjing Liu†, Rui Zhang†, Liang Cheng†, Kai Yang‡, Wei Pan#, Meifang Zhu§, Zhuang Liu†,*† |
单位： | †Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China. ‡State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China. § State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China ∥College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China |
摘要： | Brachytherapy by placing therapeutic radioactive materials into or nearby tumors has been widely used in the clinic for cancer treatment. The efficacy of brachytherapy, however, may often be limited by the radiation resistance for tumor cells located in the hypoxic region of a solid tumor, as well as the non-optimal distribution of radioactivity inside the tumor. Herein, a hybrid hydrogel system is developed by using 131I-labeled copper sulfide (CuS/131I) nanoparticles as the photothermal-/radiotherapeutic agent, poly(ethylene glycol) double acrylates (PEGDA) as the polymeric matrix, and 2, 2’-azobis[2-(2-imidazolin-2-yl) propane]dihydrochloride (AIPH) as the thermal initiator, to realize light-induced in situ gelation in the tumor for the combined photothermal-brachytherapy. After local injection, CuS/131I nanoparticles under irradiation by the 915-nm near-infrared (NIR) laser would produce heat to mildly raise the tumor temperature and initiate the polymerization of PEGDA by activating the AIPH thermal initiator, effectively fixing CuS/131I by in situ gelation within the tumor for long-term. By repeated NIR irradiation of tumors, the tumor hypoxia could be relieved for a much longer term, resulting in a significant synergistic photothermal-brachy therapeutic effect to eliminate tumors. This work presents an efficient type of NIR-responsive nanoparticle-encapsulated hydrogel system, inspiring the design of the form of brachytherapy. |
影响因子： | 13.709 |
分区情况： | 一区 |
链接： | https://pubs.acs.org/doi/abs/10.1021/acsnano.8b04544 |
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