何耀教授课题组及其合作者在ACS Nano上发表论文

题目：

Targeted Noninvasive Treatment of Choroidal Neovascularization by Hybrid Cell-Membrane-Cloaked Biomimetic Nanoparticles

作者：

Manjing Li,^1,# Zhaojian Xu,^1,# Lu Zhang,^1,# Mingyue Cui,¹ Manhui Zhu,² Yang Guo,² Rong Sun,¹ Junfei Han,¹ E Song,² Yao He,^1,* and Yuanyuan Su^3,*

单位：

¹Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China

²Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou 215123, China

³Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun YatSen University, Guangdong 510120, China

摘要：

Choroidal neovascularization (CNV) is the leading cause of vision loss in many blinding diseases, but current antiangiogenic therapies with invasively intravitreal injection suffer from poor patient compliance and a rate of devastating ocular complications. Here, we develop an alternative antiangiogenic agent based on hybrid cell-membrane-cloaked nanoparticles for noninvasively targeted treatment of CNV. The retinal endotheliocyte membrane coating provides as-fabricated nanoagents with homotypic targeting capability and binding ability to the vascular endothelial growth factor. The fusion of red blood cell membranes protects the hybrid membrane-coated nanoparticles from phagocytosis by macrophages. In a laser-induced wet age-related macular degeneration mouse model, a significantly enhanced accumulation is observed in CNV regions after intravenous delivery of the hybrid membrane-coated nanoparticles. Moreover, an excellent therapeutic efficacy is achieved in reducing the leakage and area of CNV. Overall, the biomimetic antiangiogenic nanoagents provide an effective approach for noninvasive treatment of CNV.

影响因子：

14.588

分区情况：

一区

链接：

https://pubs.acs.org/doi/10.1021/acsnano.1c00680