PENG, Rui
Ph.D., Professor
B.S., Nanjing University, Dept. of Biochemistry, 1996
M.S., Nanjing University, Dept. of Biochemistry, 1999
Ph.D., Vanderbilt University (US), Dept. of Biological Sciences, 2005
Tel: 0512-65880947 (O)
Email: rpeng@suda.edu.cn
Research Interests:
Nanobiotechnology, Molecular Cell Biology, Nano-vaccines.
As a molecular biologist, my recent interests focus on applying molecular, cellular, and nanobiology approaches to understand and control of the nano/bio and bio/bio interfaces for unveiling the biological effects of various nanomaterials and the development of their bio-applications. In particular, we engineered various functionalized nanomaterials and discovered their selective interactions with proteins (immune factors and enzymes, reported by Nanowerk) and cells (bacterial cells and immune cells). We further unveiled the mechanisms underneath, based on which we developed novel applications of such nanomaterials as nano-carriers and/or immune adjuvants, including nano-vaccines for cancer immunotherapy, antibacterial agents, as well as microbial engineering and enzyme engineering.
Research Projects:
1. Nano-carriers and/or immune adjuvants for nano-vaccines and/or cancer immunotherapy
2. Nanomaterials as antibacterial agents
3. Biological effects and applications of nanomaterials.
Selected Publications:
Chenya Wang§, Liping Zhong§, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao*, Rui Peng*, Zhuang Liu*, Oncolytic mineralized bacteria as potent locally administered immunotherapeutics, Nature Biomedical Engineering, 2024, DOI: 10.1038/s41551-024-01191-w
Qi Zhuang, Ting Chao, Yuanyuan Wu, Ting Wei, Jiacheng Ren, Zhiqing Cao, Rui Peng*, Zhuang Liu*, Fluorocarbon modified chitosan to enable transdermal immunotherapy for melanoma treatment, Small, 2023,19, 2303634.
Fengyun Shen, Lele Sun*, Lihua Wang, Rui Peng*, Chunhai Fan, and Zhuang Liu*. Framework Nucleic Acid Immune Adjuvant for Transdermal Delivery Based Chemo-immunotherapy for Malignant Melanoma Treatment, Nano Letters, 2022, 22, 4509−4518
Qi Zhuang, Jun Xu, Dashi Deng, Ting Chao, Junyan Li, Rui Zhang, Rui Peng*, Zhuang Liu*. Bacteria-derived membrane vesicles to advance targeted photothermal tumor ablation, Biomaterials, 2021, 268, 120550-120563
Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng* and Zhuang Liu*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nature Nanotechnology, 2020, 15, 1043-1052
Fengyun Shen, Liangzhu Feng*, Yujie Zhu, Danlei Tao, Jun Xu, Rui Peng*, Zhuang Liu*. Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemoimmunotherapy of colorectal cancer. Biomaterials, 2020, 255, 120190
Chenya Wang§, Yuanpeng Xiao§, Wenwen Zhu, Jiacheng Chu, Jun Xu, He Zhao, Fengyun Shen, Rui Peng*, and Zhuang Liu*. Photosensitizer-Modified MnO2 Nanoparticles to Enhance Photodynamic Treatment of Abscesses and Boost Immune Protection for Treated Mice. Small, 2020, 2000589
Jun Xu, Hui Wang, Ligeng Xu, Yu Chao, Chenya Wang, Xiao Han, Ziliang Dong, Hong Chang, Rui Peng*, Yiyun Cheng*, Zhuang Liu*. Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy, Biomaterials, 2019, 207, 1-9
Rong Yang, Jun Xu, Ligeng Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng*, and Zhuang Liu*. Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination. ACS Nano, 2018, 12, 5121-5129
Edited by Juan Yang